Well, at least a few folks seem to think the Sox have a chance. From bullz-eye.com , http://www.bullz-eye.com/sports/features/2010/mlb_preview.htm posted by Anthony Statler. For his 2010 MLB preview, he writes about what he considers the 5 teams that didn't make the playoffs last year that have the best shot at it this year. He picks the White Sox at #1 with some sound reasoning behind it.
He also picks the South Siders to win the division and even make the WS in one scenario.