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1933
The first-ever All-Star Game was played at Comiskey Park. The White Sox won a coin flip with the Cubs for the right to host the game that was the idea of Chicago Tribune sports editor Arch Ward. The American League won the game, 4-2, thanks to a home run by Babe Ruth in the third inning off of Bill Hallahan.
The Sox representatives in that first game were Jimmy Dykes (3B) and Al Simmons (OF). Dykes scored the first-ever All-Star run.
1954
Virgil Trucks threw a one-hitter at Detroit, beating the Tigers, 4-0. It would be the second one-hitter thrown by Trucks in little more than two months. On May 1, he beat Boston at Fenway Park, 3-0, with a one-hitter. In this game, the only hit Trucks allowed came in the third inning, when Harvey Kuenn singled to center.
1983
The golden anniversary All-Star Game was held at Comiskey Park. The American League mangled the National League, 13-3, stopping an 11-game losing streak. Chicago native Fred Lynn of the Angels hit the game’s first-ever grand slam, off of San Francisco’s Atlee Hammaker (who’d later go on to pitch for the Sox).
Ron Kittle (OF), who’d go on to win the Rookie of the Year, got an infield single in the game. He was the South Siders’ lone representative.
1999
Chris Singleton became the first White Sox rookie to ever hit for the cycle, when he turned the trick against Kansas City. The Sox would lose the game, however, 8-7, in 10 innings.
Singleton would later go on to be a Sox broadcaster for a short period of time.
2007
The Minnesota Twins scored 32 runs and hammered eight home runs in a day/night twin bill at U.S. Cellular Field, winning 20-14 and 12-0. It was a low point for a franchise that had won the World Series less than two years earlier.